Will Ferrell
Postać: Megamind (voice)
Brad Pitt
Postać: Metro Man (voice)
Tina Fey
Postać: Roxanne Ritchi (voice)
Jonah Hill
Postać: Titan (voice)
David Cross
Postać: Minion (voice)
Ben Stiller
Postać: Bernard (voice)
Justin Theroux
Postać: Megaminds's Father (voice)
Jessica Schulte
Postać: Megamind's Mother (voice)
Tom McGrath
Postać: Lord Scott / Prison Guard (voice)
Emily Nordwind
Postać: Lady Scott (voice)
J.K. Simmons
Postać: Warden (voice)
Ella Olivia Stiller
Postać: Schoolchild (voice)
Quinn Dempsey Stiller
Postać: Schoolchild (voice)
Brian Hopkins
Postać: Prisoner (voice)
Christopher Knights
Postać: Prison Guard (voice)
Mike Mitchell
Postać: Father in Crowd (voice)
Jasper Johannes Andrews
Postać: Crying Baby (voice)
Justin Long
Postać: Minions (voice)
Bill Hader
Postać: Bob Prickles (voice)
Amy Poehler
Postać: Linda Prickles (voice)
Rob Corddry
Postać: Random Citizen (voice)
Jack Blessing
Postać: Newscaster (voice)
Stephen Kearin
Postać: Mayor (voice)
