Johnny Depp
Postać: Rango (voice)
Isla Fisher
Postać: Beans (Voice)
Ned Beatty
Postać: Tortoise John (voice)
Bill Nighy
Postać: Rattlesnake Jake (voice)
Alfred Molina
Postać: Roadkill (Voice)
Abigail Breslin
Postać: Priscilla (Voice)
Claudia Black
Postać: Angelique (voice)
Timothy Olyphant
Postać: The Spirit of the West (voice)
Ray Winstone
Postać: Bad Bill (voice)
Stephen Root
Postać: Doc / Merrimack / Mr. Snuggles (voice)
Harry Dean Stanton
Postać: Balthazar (voice)
Ian Abercrombie
Postać: Ambrose (voice)
Gil Birmingham
Postać: Wounded Bird (voice)
James Ward Byrkit
Postać: Waffles / Gordy / Papa Joad / Cousin Murt / Curlie / Knife Attacker / Rodent Kid (voice)
Blake Clark
Postać: Buford (voice)
Keith Campbell
Postać: Sod Buster (voice)
Beth Grant
Postać: Bonnie (voice)
