Jack Black
Postać: Po (voice)
Angelina Jolie
Postać: Tigress (voice)
Dustin Hoffman
Postać: Shifu (voice)
Gary Oldman
Postać: Lord Shen (voice)
Jackie Chan
Postać: Monkey (voice)
Lucy Liu
Postać: Viper (voice)
Seth Rogen
Postać: Mantis (voice)
David Cross
Postać: Crane (voice)
Michelle Yeoh
Postać: The Soothsayer (voice)
James Hong
Postać: Mr. Ping (voice)
Danny McBride
Postać: Wolf Boss (voice)
Dennis Haysbert
Postać: Master Storming Ox (voice)
Jean-Claude Van Damme
Postać: Master Croc (voice)
Victor Garber
Postać: Master Thundering Rhino (voice)
Mike Bell
Postać: Gorilla Guard 1 (voice) (as Michael Patrick Bell)
Jason Bertsch
Postać: Antelope Driver (voice)
Michael DeMaio
Postać: Happy Bunny (voice)
Shane Glick
Postać: Wolf Soldier 4 (voice)
Lena Golia
Postać: Pig Fan / Bunny (voice)
April Hong
Postać: Mop Bunny (voice)
Joseph Izzo
Postać: Wolf Soldier 1 (voice)
Alexandra Gold Jourden
Postać: Bunny Fan (voice) (as Alexandra Jourden)
Stephen Kearin
Postać: Musician Pig / Awesome Pig (voice)
Liam Knight
Postać: Baby Po (voice)
Paul Mazursky
Postać: Musician Bunny (voice)
Dan O'Connor
Postać: Stain Pig / Wolf Soldier 2 (voice)
Jeremy Shipp
Postać: Dumpling Bunny (voice)
Maury Sterling
Postać: Wolf Soldier 3 (voice)
Fred Tatasciore
Postać: Panda Dad / Gorilla Guard 2 (voice)
Lauren Tom
Postać: Market Sheep (voice)
Romy Rosemont
Postać: Pig Mother (voice)
Conrad Vernon
Postać: Boar (voice)
