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histopathology:lexicon
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histopathology:lexicon [2016/07/19 09:52] pkleczek [Rozplem] |
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| - | ~~NOTRANS~~ | ||
| - | ====== Leksykon ====== | ||
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| - | ===== Rozplem ===== | ||
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| - | ([[http://sjp.pwn.pl/doroszewski/rozplem;5492210.html|SJP PWN]]) | ||
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| - | - rozmnażanie się, rozrost komórek w organizmie; | ||
| - | - nadmierne powiększanie się jakiegoś narządu na skutek rozrostu jego komórek | ||
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| - | ===== Monomorfizm ===== | ||
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| - | jednakowe cechy cytologiczne komórek guza | ||
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| - | ===== Gniazdo komórkowe ===== | ||
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| - | (tu: gniazdo melanocytów; nest of melanocytes, melanocytic nest) | ||
| - | małe zgrupowanie komórek danego typu, innych od pozostałych komórek w tkance ([Medical Dictionary for the Health Professions and Nursing, Farlex 2012]) | ||
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| - | [{{:histopathology:lexicon:nest_melanocytes.jpg?direct&200|Gniazdo melanocytów tworzące strukturę neuroidalną przypominającą ciałko Pacciniego, otoczone jest przez śluzowaciejące podścielisko. (Źródło: [[https://commons.wikimedia.org/wiki/File:SkinTumors-336.jpg|wiki]])}}] | ||
| - | |||
| - | ===== Kariocyt ===== | ||
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| - | dowolna komórka posiadająca jądro | ||
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| - | ===== Scanning magnification ===== | ||
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| - | powiększenie umożliwiające szybką całościową ocenę zmiany (2-5x) | ||
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| - | ===== Eozynofilny, eozynochłonny ===== | ||
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| - | barwiący się na różowo przy barwieniu H&E | ||
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| - | ===== Mitoza ===== | ||
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| - | [{{:histopathology:lexicon:mitosis1.jpg?direct&200|Mitoza (źródło: [[http://www.pathpedia.com/education/eatlas/histopathology/skin_and_adnexa/melanoma_balloon_cell_type.aspx|PathPedia]])}}] | ||
| - | [{{:histopathology:lexicon:atypical_mitosis.jpg?direct&200|Atypowe mitozy (źródło: [[http://www.pathologystudent.com/wp-content/uploads/2012/07/mitoses1.jpg|Pathology Student]])}}] | ||
| - | <WRAP clear/> | ||
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| - | [http://www.pathologystudent.com/?p=5689] | ||
| - | My general rule of thumb is to look for an elongated dark blob. I know this isn’t very eloquent or scientific-sounding, but there you go. Check out the image above: there are three mitotic figures, and the ones at 3 o’clock and 5 o’clock like little black bars. These little bars represent the chromosomes all lined up in metaphase, getting ready to separate. It’s pretty distinctive; there aren’t many other things that look like this. | ||
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| - | The problem is when you see a dark thing that’s not really an elongated bar shape, but more of a rounded blob. There are other things that can look like little dark dots, notably cells undergoing apoptosis. In apoptosis, the nucleus becomes pyknotic (it shrinks and becomes a dark, dense dot). It can be hard to tell an apoptotic cell apart from a cell undergoing mitosis, particularly when the shape is sort of in between, like the circled cell at 11 o’clock (which I would call a mitotic figure). This is the sort of thing that you become better at with practice. When you look at slides with someone more experienced, your eye will become trained on this and other topics. Be sure to speak up when you have questions! | ||
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| - | There is a special type of mitotic figure called a tripolar mitosis that you should be aware of. It’s called tripolar because there are three radiating spokes coming out from a center hub; it looks like a little Mercedes sign. This type of mitotic figure indicates that mitosis is not proceeding normally. Tripolar mitoses (or, by the way, any mitotic figures with odd numbers of spokes) are considered definitive signs of malignancy; you just don’t see them in normally-dividing cells. | ||
histopathology/lexicon.1468914746.txt.gz · Last modified: 2020/03/25 11:46 (external edit)
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